A Practical Method for Optical Resolution of 1,1'-Binaphtyl-2,2'-dicarboxylic Acid via 1-Phenylethylamides

Article abstract of DOI:10.1246/bcsj.62.956

Both enentiomers of 1,1'-binaphthyl-2,2'-dicarboxylic acid (100percent ee's by HPLC) were conveniently obtained in high yields (ca. 80percent of the theory) via fractional crystallization of the (S)-1-phenylethylamide diastereomers of the racemic acid followed by treatment with thionyl chloride and then alkaline hydrolysis