Oligonucleotides with alternating anionic and cationic phosphoramidate linkages: Synthesis and hybridization of stereo-uniform isomers

Article abstract of DOI:10.1016/0040-4039(95)02309-7

An oligonucleotide containing alternating anionic and stereo-uniform cationic dimethylaminopropyl-phosphoramidate linkages, d(T+T-)₇T, is shown to bind with unusually high affinity to DNA [poly(dA) and d(C₂A₁₅C₂)] and RNA [poly(rA)] targets in solutions of low ionic strength. The isomeric oligomer with the opposite configuration at the phosphoramidate links binds much less efficiently.