Journal of Medicinal Chemistry p. 912 - 918 (1993)
Update date:2022-08-17
Topics:
Tupper, David E.
Pullar, Ian A.
Clemens, James A.
Fairhurst, John
Risius, Francesca C.
et al.
A series of 2-thioether derivatives of a number of clavine alkaloid (ergoline) ring systems have been synthesized and tested for dopamine antagonist activity.Of the compounds tested 2-(methylthio)agroclavine (8,9-didehydro-6,8-dimethyl-2-(methylthio)ergoline) (6) was the most potent and had a profile of activity in animal models indicative of potential antipsychotic activity.The synthesis and biological activity of a number of metabolites of 6, including the 13-hydroxy derivative, are also reported.
View More
Huaihua Baohua Biotechnology Co.,Ltd
website:http://www.baochengchem.com
Contact:86-519-82698291
Address:HouYang chemical development zone,Jintan,Jiangsu,China (213200)
Zhejiang kehong chemical co., ltd
Contact:0086-575-85522000
Address:xiner center RD binhai industrial zone shaoxing zhejiang province P.R.China,312073
Shanghai Dianyang Industry Co.,ltd
Contact:+86 21 6492 4669
Address:Chejing RD, Songjiang District, Shanghai, China
Shanghai PengMo Biotechnology Co.,Ltd
website:http://www.pengmobio.lookchem.com
Contact:86-13052359378
Address:No.218 Hai Qu Road.Shanghai.China
Contact:+86 021-51698675
Address:1701, Jielong Plaza, No.618 Pingliang Rd, ShangHai,China
Doi:10.3390/molecules180910912
(2013)Doi:10.1248/cpb.38.993
(1990)Doi:10.1055/s-0040-1707099
(2020)Doi:10.1089/ars.2010.3190
(2011)Doi:10.1055/s-1977-24486
(1977)Doi:10.1021/jo034402b
(2003)
