Activities of morphinone and N-(cyclopropylmethyl)normorphinone at opioid receptors

DOI: 10.1021/jm00376a026

Source and publish data:

Journal of Medicinal Chemistry p. 1361 - 1363 (1984)

Update date:2022-08-11

Topics:

Authors:

Fang Fang

Takemori

Portoghese

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Article abstract of DOI:10.1021/jm00376a026

Morphinone (3) and N-(cyclopropylmethyl)normorphinone (4) were synthesized and tested on electrically stimulated smooth muscle preparations (guinea pig ileum and mouse vas deferens) and in mice. Compound 3 behaved as an agonist and 4 as an antagonist in vitro and in vivo. No pronounced nonequilibrium agonist or antagonist activity was observed with either compound.

Full text of DOI:10.1021/jm00376a026

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Product name:N-(cyclopropylmethyl)normorphine

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