Tetrahedron Letters p. 1783 - 1784 (1998)
Update date:2022-08-29
Topics:
Wu, Ying-Ta
Hsieh, Hsing-Pang
Wu, Chi-Yu
Yu, Hui-Ming
Chen, Shui-Tein
Wang, Kung-Tsung
A new procedure is described for the synthesis of octreotide and its analogs using p-carboxybenzaldehyde as a linker to anchor Fmoc-threoninol to solid phase resins. Fmoc-threoninol reacted with p-carboxybenzaldehyde to form Fmoc-threoninol p-carboxybenzacetal in 95% yield. The Fmoc-threoninol p- carboxybenzacetal was coupled to an amine-resin and octreotides were successfully synthesized with yields of 74-76%.
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