Suppression of morphine and cocaine self-administration in rats by a mixed mu antagonist-kappa agonist (N-CBM-TAMO) and a long-acting selective D1 antagonist (AS-300)

Article abstract of DOI:10.1016/0960-894X(96)00186-2

N-CBM-TAMO 2 was prepared by the same procedure as used for TAMO 1. It was found to be a short-term kappa agonist and a long-term mu antagonist. The benzazepine 12, (AS-300) was a potent selective D₁ antagonist. Both compounds suppressed cocaine and morphine self-administration in rats at doses which did not affect water consumption.