
Bioorganic and Medicinal Chemistry Letters p. 1139 - 1144 (1996)
Update date:2022-08-22
Topics:
Archer, Sydney
Glick, Stanley D.
Maisonneuve, Isabelle M.
Bidlack, Jean M.
Xu, Jimmy Y.
Teitler, Milt
Sebastian, Alice
El-Hamouly, Wageeh
Hutchinson, Ian
N-CBM-TAMO 2 was prepared by the same procedure as used for TAMO 1. It was found to be a short-term kappa agonist and a long-term mu antagonist. The benzazepine 12, (AS-300) was a potent selective D1 antagonist. Both compounds suppressed cocaine and morphine self-administration in rats at doses which did not affect water consumption.
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