Scorpio-Ligand: Synthesis of Biphenyl-Dihydroazepine Phosphoramidite Ligands for Asymmetric Hydrogenation

Article abstract of DOI:10.1002/hlca.202100147

A novel dihydroazepine-bridged BIPHEP phosphoramidite ligand with an amino acid moiety in the backbone was synthesized and evaluated in the Rh-catalyzed asymmetric hydrogenation. The scorpion tail-like amino acid backbone is capable of hydrogen bond forma

Full text of DOI:10.1002/hlca.202100147

HELVETICA
chimica acta
Accepted Article
Title: Scorpio-Ligand: Synthesis of Biphenyl-Dihydroazepine
Phosphoramidite Ligands for Asymmetric Hydrogenation
Authors: Stefanie Auras and Oliver Trapp
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To be cited as: Helv. Chim. Acta 10.1002/hlca.202100147
Link to VoR: https://doi.org/10.1002/hlca.202100147
www.helv.wiley.com

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10.1002/hlca.202100147
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Helvetica Chimica Acta
10.1002/hlca.202100147
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Helvetica Chimica Acta
10.1002/hlca.202100147
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Helvetica Chimica Acta
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10.1002/hlca.202100147
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퐴1 (ꢀ푎푥)
with 퐾 = 퐴2 (푆푎푥)
°
∆
퐺 = −푅푇 ∙ ln퐾
°

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Helvetica Chimica Acta
10.1002/hlca.202100147
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
ꢂ푟푎푐
ꢃ
ꢄ
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ln ꢅ
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ꢃ∆푡
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Δ
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Δ
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Helvetica Chimica Acta
10.1002/hlca.202100147
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This article is protected by copyright. All rights reserved.

Helvetica Chimica Acta
10.1002/hlca.202100147
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This article is protected by copyright. All rights reserved.

Helvetica Chimica Acta
10.1002/hlca.202100147
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This article is protected by copyright. All rights reserved.

Helvetica Chimica Acta
10.1002/hlca.202100147
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This article is protected by copyright. All rights reserved.

Helvetica Chimica Acta
10.1002/hlca.202100147
HELVETICA
This article is protected by copyright. All rights reserved.

Helvetica Chimica Acta
10.1002/hlca.202100147
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This article is protected by copyright. All rights reserved.