Investigative studies on the formation of the imidazo [4',5':3,4]pyrido[2,3-b]indole ring: Formal synthesis of the alkaloids grossularines-1 and 2. X-ray crystal structures of 5-indol-3-yl-imidazole and bisimidazocarbazole derivatives

Article abstract of DOI:10.1016/S0040-4020(98)00520-1

Reactions of several 2,3-disubstituted indoles, bearing a chlorine or amino function at position 2 and an 1,2-dicarbonyl group or bromoacetyl substituent at position 3, with N,N-dimethylguanidine is reported. In general, 5-indol-3-yl imidazole derivatives