The synthesis and antiviral activity of 4-fluoro-1-β-D-ribofuranosyl- 1h-pyrazole-3-carboxamide

Article abstract of DOI:10.1080/15257779908043068

A novel fluoropyrazole ribonucleoside has been shown to have significant antiinfluenza activity in vitro. The compound is compared and contrasted with the structurally-related compound ribavirin in attempts to identify factors having significant bearing on the mode of action of both compounds.

Full text of DOI:10.1080/15257779908043068

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Nucleosides and Nucleotides
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The Synthesis and Antiviral Activity
of 4-Fluoro-1-β-D-ribofuranosyl-1H-
pyrazole-3-carboxamide
a
a
a
Richard Storer , Claire J. Ashton , Anthony D. Baxter , Michael
a
a
a
a
M. Hann , Clara L.P. Marr , Andrew M. Mason , Chi-Leung Mo
a
a
a
,
Peter L. Myers , Stewart A Noble , Charles R. Penn , Niall G.
a
a
a b
Weir , Jacqueline M. Woods & Paul L. Coe
a
GlaxoWellcome Research and Development, Medicines Research
Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK
b
School of Chemistry, University of Birmingham, Birmingham, B15
2TT, UK
Version of record first published: 04 Oct 2006
To cite this article: Richard Storer, Claire J. Ashton, Anthony D. Baxter, Michael M. Hann, Clara L.P.
Marr, Andrew M. Mason, Chi-Leung Mo, Peter L. Myers, Stewart A Noble, Charles R. Penn, Niall G.
Weir, Jacqueline M. Woods & Paul L. Coe (1999): The Synthesis and Antiviral Activity of 4-Fluoro-1-β-
D-ribofuranosyl-1H-pyrazole-3-carboxamide, Nucleosides and Nucleotides, 18:2, 203-216
To link to this article: http://dx.doi.org/10.1080/15257779908043068
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