Synthesis of novel analogues of the delta opioid ligand SNC-80 using AlCl3-promoted aminolysis

Article abstract of DOI:10.1016/S0960-894X(99)00174-2

Two focused libraries of delta opioid ligands were synthesised using AlCl₃ facilitated aminolysis. Several compounds were identified with DOR binding affinities higher or similar to SNC-80. A novel acyclic derivative of SNC-80 produced antinoci