Nucleosides, nucleotides and nucleic acids p. 163 - 177 (2016)
Update date:2022-08-11
Topics:
Tauraite, Daiva
Ra?anas, Rytis
Mikalkenas, Algirdas
Serva, Saulius
Me?kys, Rolandas
The synthesis and characterization of novel acyclic and cyclic pyridone-based nucleosides and nucleotides is described. In total, seven nucleosides and four nucleotides were synthesized. None of the tested nucleosides showed inhibitory properties against Klenow exo- polymerase and M.MuLV and HIV-1 reverse transcriptases. The nucleotides containing 4-chloro- and 4-bromo-2-pyridone as a nucleobase were accepted by the Klenow fragment, but at the expense of fidelity and extension efficiency.
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(2016)