Chemical and Pharmaceutical Bulletin p. 905 - 906 (1999)
Update date:2022-08-25
Topics:
Takeuchi, Yasuo
Abe, Hitoshi
Harayama, Takashi
Racemic compounds (1 and 2) of the antimalarial agents febrifugine (d- l) and isofebrifugine (d-2) were synthesized using an unusual Claisen rearrangement of allyl enol ether (7) and the stereoselective reduction of 2- allyl-3-piperidone (8). This method is widely applicable to the synthesis of derivatives needed to study the structure-activity relationship of febrifugine.
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