DRIMANE-TYPE SESQUITERPENOIDS FROM THE LIVERWORT MAKINOA CRISPATA

Article abstract of DOI:10.1016/0031-9422(89)80351-6

Three new drimane-type sesquiterpenoids, 7α-chloro-6β-hydroxyconfertifoline, 6β,7α-dihydroxyconfertifoline and 6β,7β-epoxyconfertifoline were isolated from the liverwort Makinoa crispata together with the previously known eudesmane-type sesquiterpene lactone, crispatanolide and a sacculatane-type diterpene dialdehyde, perrottetianal A.The stereostructures of the new compounds were established by 2D NMR and CD spectroscopy and chemical evidence.The present chemical results support Schuster's phylogenic classification of the two orders, Metzgeriales and Jungermanniales.Key Word Index - Makinoa crispata; Metzgeriales; Hepaticae; crispatanolide; 7α-chloro-6β-hydroxyconfertifoline; 6β,7α-dihydroxyconfertifoline; 6β,7β-epoxyconfertifoline; drimane-type sesquiterpenoid; chemosystematics.