Enzymatic resolution of the sterically hindered myo-inositol derivative

Article abstract of DOI:10.1246/bcsj.68.1200

A modification of the enzymatic resolution has been developed for the resolution of the sterically hindered myo-inositol derivative. In this method, a side chain, which contains a terminal hydroxyl group on it, was introduced to a chiral hydroxyl group, and the terminal hydroxyl group on side chain was used for resolution. Enzymes could recognize the asymmetric center through the distal terminal hydroxyl group. Racemic 3,4,5,6-O-tetrabenzyl-myo-inositol was resolved by this method.