Hydroxylating Activity of a Water-soluble Manganese Porphyrin Associated with Potassium Hydrogen Persulfate: Formation of 8-hydroxyadenosine-5'-mono-phosphate from AMP.

Article abstract of DOI:10.1016/S0040-4039(00)82411-9

The associacion of potassium monopersulfate, KHSO5, with a wather-soluble manganese porphyrin complex has been recently reported as being a very efficient system for the oxidative cleavage of DNA (Fouquet et al., J.Chem.Soc., Chem.Commun., 1987, 1169); similar results are observed with RNA.As puzzle piece of the mechanism of this oxidative degradation of nucleic acids, we report in the present communications the identification of 8-hydroxyadenosine-5'-monophosphate as oxidation product of adenosine-5'-monophosphate (AMP) by KHSO5/(OAc)5.In the absense of manganese catalyst, the only detectable compound is the adenosine-N¹-5'-monophosphate.