A NEW SOLID PHASE APPROACH FOR RAPID SYNTHESES OF OLIGONUCLEOTIDES BEARING A 3'-TERMINAL PHOSPHATE GROUP

Article abstract of DOI:10.1016/0040-4039(84)80042-8

Synthesis of pentanucleotide ApTpCpTpTp containing a 3'-terminal phosphomonoester group was accomplished with the help of the new phosphate-solid phase link 2-(4-carboxyphenylmercapto)ethanol; a similar molecule, 2-benzylsulfonylethanol, revealed interesting features as a temporary 3'-phosphate protecting group.