Tetrahedron Letters p. 5607 - 5610 (1997)
Update date:2022-08-29
Topics:
Hong, Yaping
Tanoury, Gerald J.
Wilkinson, H. Scott
Bakale, Roger P.
Wald, Stephen A.
Senanayake, Chris H.
Palladium-catalyzed selective amination of 4-fluorobenzyl-2-chlorobenzimidazole with 4-aminopiperidine provided a simple solution for the norastemizole synthesis. Pd-catalyzed amination of other 2-chloro-1,3-Azole derivatives are exploited.
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