Asymmetric total synthesis of (+)-phomalactone, (+)-acetylphomalactone and (+)-asperlin utilizing a novel syn-selective C4-oxa-vinylogous urethane

Article abstract of DOI:10.1016/S0040-4039(98)02675-6

The total synthesis of three natural products isolated from Nigrospora sp., Phoma sp., and Aspergillus nidulans starting from an aldol reaction with a homochiral C₄-oxa-vinylogous urethane is described. Inherent stereoselectivity of the aldol reaction and overall alacrity of molecular construction are discussed.