Bioorganic and Medicinal Chemistry Letters p. 2547 - 2548 (2000)
Update date:2022-08-11
Topics:
Kehler, Jan
Hansen, Henrik I.
Sanchez, Connie
1-Propylbutylphosphinic acid 2, (1-propylbutyl)methylphosphinic acid 3 and 1-propylbutylphosphonic acid 4 have been synthesized as bioisosteres of the corresponding carboxylic acid valproate 1, which is a potent anticonvulsant. The novel phosphinic and phosphonic acids were tested for their anticonvulsant activity and were found to be inactive. (C) 2000 Elsevier Science Ltd.
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