Organic Letters
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In conclusion, we have developed palladium-catalyzed
controllable redox Heck coupling reactions of cyclic enones
with thiophene or furan under mild conditions. A variety of β-
heteroarylated cyclic ketones/enones could be rapidly accessed
by this streamlined strategy. Efforts on extending these
controllable transformations to other aromatic substrates and
olefins as well as systematic understanding mechanisms are in
progress in our laboratory.
ASSOCIATED CONTENT
* Supporting Information
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S
The Supporting Information is available free of charge on the
Detailed experimental procedures and spectral data for
AUTHOR INFORMATION
Corresponding Authors
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(5) Cacchi, S.; Arcadi, A. J. Org. Chem. 1983, 48, 4236.
(6) (a) Raoufmoghaddam, S.; Mannathan, S.; Minnaard, A. J.; de
Vries, J. G.; Reek, J. N. H. Chem. - Eur. J. 2015, 21, 18811.
(b) Gottumukkala, A. L.; de Vries, J. G.; Minnaard, A. J. Chem. - Eur.
J. 2011, 17, 3091.
ORCID
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Jordan-Hore, J. A.; Lee, A. L. Org. Lett. 2013, 15, 1886.
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Notes
The authors declare no competing financial interest.
(10) (a) Gurak, J. A., Jr; Engle, K. M. ACS Catal. 2018, 8, 8987.
(b) Tran, V. T.; Gurak, J. A., Jr; Yang, K. S.; Engle, K. M. Nat. Chem.
2018, 10, 1126.
(11) Wen, Z. K.; Song, T. T.; Liu, Y. F.; Chao, J. B. Chem. Commun.
2018, 54, 3668.
ACKNOWLEDGMENTS
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This work was financially supported by the National Natural
Science Foundation of China (21502106), the National
Natural Science Foundation for Young Scientists of Shanxi
Province (201701D221028), and the Ministry of Human
Resources and Social Security Foundation of China for High-
level Returned Talents. We are also very grateful for the test
platform provided by Scientific Instrument Center of Shanxi
University.
(12) (a) Chung, L. G. Y.; Juwaini, N. A. B.; Seayad, J. ChemCatChem
̈
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