Journal of Organic Chemistry p. 2747 - 2750 (1993)
Update date:2022-08-11
Topics:
Echalier, Frederique
Constant, Olivier
Bolte, Jean
This paper reports the activity of glutamic oxalacetic aminotransferase (GOT) from pig heart and bacteria for racemic 4-hydroxy-, 4-methyl-, and 4-ethyl-2-ketoglutaric acids.These compounds are good substrates for GOT with Vmax values of, respectively, 70, 90, and 130 percent relative to the natural substrate, 2-ketoglutaric acid.GOT displays high enantioselectivity toward 4-methyl-2-ketoglutaric acid and 4-ethyl-2-ketoglutaric acid; the synthesis of both diastereoisomers of the corresponding 4-substituted L-glutamic acids is thus possible.
View MoreTaizhou Elitechemie MediPharma Technology Co.,Ltd.
Contact:+86-523-86810021
Address:Building G14,NO.1 Avenue,China Medical City, Taizhou, Jiangsu,China
Zhejiang Hoshine Silicon Industry Co., Ltd.
Contact:86-573-89179966
Address:Zhapu Town, Pinghu City, Zhejiang, China
Contact:+86 21 5017 5386
Address:No 999,Jiangyue Rd, Minhang Dist ,201114,Shanghai ,China
SHANDONG ZHANHUA YONGHAO PHARMACEUTICAL TECH.CO.,LTD
Contact:+86-576-88685096
Address:GENGJU VILLAGE NORTH ONE KILOMETER,ZHANHUA DISTRICT,BINZHOU CITY,SHANDONG PROVINCE,CHINA.
Contact:+86-21-6856-1349 523-87676172
Address:No16 . BinJiang Road . Taixing Economy Developing Area .JiangSu Province . China
Doi:10.1039/c8ra08624a
(2018)Doi:10.1016/j.mencom.2013.09.006
(2013)Doi:10.1021/jo061502j
(2006)Doi:10.1002/zaac.200390102
(2003)Doi:10.1021/j100341a070
(1989)Doi:10.1016/S0040-4039(01)85785-3
(1978)