Total synthesis of (+)-cyclomyltaylan-5α-ol isolated from the Taiwanese Liverwort Reboulia hemisphaerica

Article abstract of DOI:10.1016/S0040-4039(99)00338-X

The novel tetracyclic sesquiterpenoid (+)-cyclomyltaylan-5α-ol 1 has been synthesized starting from (S)-(+)-Hajos-Wiechert ketone analogue 3 via Sml₂-promoted reductive cyclization as a key step. Thus, the absolute configuration has been established to be 2R,3R,4R,5S,6R,7R (cyclomyltaylane numbering) as depicted in structure 1.