A Short Route to 2-(6-Methoxycarbonylhexyl)-cyclopent-2-en-1-one

Article abstract of DOI:10.1055/s-1986-31618

The prostaglandin intermediate 2-(6-methoxycarbonylhexyl)-cyclopent-2-en-1-one (5) has been prepared by a short synthetic sequence, consisting of the reaction of 2-(1,3-dioxolan-2-yl)-ethylmagnesium bromide (1) with methyl 9-chloro-9-oxononanoate (2), followed by cleavage of the dioxolane ring of 3 and base-induced cyclisation of 4.