An efficient synthesis of 2,3,5-trisubstituted furans from α,β- unsaturated ketones

Article abstract of DOI:10.1016/S0040-4020(99)00898-4

A simple, regioselective synthesis of 2,3,5-trisubstituted furans is described. Conjugate addition of alkynylboronates to α,β-unsaturated ketones, followed by acid-catalyzed cyclization of the resulting γ-alkynyl ketones affords trisubstituted furans in 3197% overall yields.