Asymmetric synthesis of α-aminophosphonates via diastereoselective addition of phosphite to chiral imine derivatives

Article abstract of DOI:10.1016/0957-4166(95)00411-4

One pot three component reactions employing homochiral (1S)-(+)-camphorsulfon-amide-derived carbamate, aldehydes and diethyl phosphite at 0°C was found to give protected (S)-α-aminophosphonates in high enantiomeric purities.