A facile one-pot synthesis of vinpocetine

Article abstract of DOI:10.1080/00397919408011297

A one-pot synthesis of vinpocetine from vincamine was established. Lewis acids caused transesterification and/or dehydration of vincamine in EtOH. FeCl₃ catalyzed both transesterification and dehydration while Ti(OEt)₄ selectively catalyzed transesterification.

Full text of DOI:10.1080/00397919408011297

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Synthetic Communications: An
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A Facile One-Pot Synthesis of
Vinpocetine
Yukihiro Kuge a , Hideo Nakazawa a , Toru Kometani a
, Toru Sugaya a , Kenichi Mochida a & Shinji Tomioka
b
a Sakai Research Laboraroties, Kyowa Hakko Kogyo
Co. Ltd., 1-1-53, Takasu-cho, Sakai-shi, Osaka, 590,
Japan
b Tokyo Research Laboratories, Kyowa Hakko Kogyo
Co. Ltd., 3-3-6, Asahi-cho, Machida-shi, Tokyo, 194,
Japan
Version of record first published: 16 Feb 2007.
To cite this article: Yukihiro Kuge, Hideo Nakazawa, Toru Kometani, Toru Sugaya,
Kenichi Mochida & Shinji Tomioka (1994): A Facile One-Pot Synthesis of Vinpocetine,
Synthetic Communications: An International Journal for Rapid Communication of
Synthetic Organic Chemistry, 24:6, 759-766
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