Diastereoselective addition of α-hydroxyalkyl and α-alkoxyalkyl radicals to chiral 4-methyleneoxazolidin-5-ones

Article abstract of DOI:10.1016/S0040-4020(98)00259-2

A method for preparing optically active homoserine derivatives via the photoinduced radical additions of alcohols and ethers to the chiral 4- methyleneoxazolidin-5-ones 1 and 2 has been achieved. These photoadducts, however, are readily prone to epimerization under the conditions required for their deprotection.