Dimethyl 2,6-dimethyl-4-(3-nitrophenyl)-pyridine-3,5-dicarboxylate, diethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and diethyl 2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate

Article abstract of DOI:10.1107/S0108270196000091

The crystal structure of diethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, C₁₉H₂₂N₂O₆ (FR7534), a member of the 1,4-dihydropyridine class of calcium blockers, and the crystal structures of diethyl 2,6-dimethyl-4-(3-nitrophenyl)-pryridine-3,5-dicarboxylate, C₁₉H₂₀N₂O₆, and dimethyl 2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate, C₁₇H₁₆N₂O₆, decomposition products of FR7534 and dimethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, respectively, reveal that the decomposition products display conformational features associated with activity according to structure-activity relationship.