Archiv der Pharmazie p. 303 - 305 (1994)
Update date:2022-08-12
Topics:
Echevarria
Martin
Perez
Rozas
Theoretical studies by shape analysis of the molecular electrostatic potential on the van der Waals surfaces of a set of 4-alkylpyrazoles predicted 4-isopentyl derivative as a good inhibitor of liver alcohol dehydrogenase. Thus, the new 4-isopentyl and the already known 4-octylpyrazole have been prepared by a novel route. The isopentyl derivative has been tested as inhibitor of horse liver alcohol dehydrogenase giving the result predicted by the theoretical studies.
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(1993)
