Antitumor agents 201. Cytotoxicity of harmine and β-carboline analogs

DOI: 10.1016/S0960-894X(99)00598-3

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3319 - 3324 (1999)

Update date:2022-08-10

Topics:

Authors:

Ishida, Junko

Wang, Hui-Kang

Bastow, Kenneth F.

Hu, Chang-Qi

Lee, Kuo-Hsiung

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Article abstract of DOI:10.1016/S0960-894X(99)00598-3

Twenty-six β-carbolines were evaluated for in vitro cytotoxicity in a human tumor cell line panel. Harmine (3) showed significant activity against several cell lines including three drug-resistant KB sublines with various resistance mechanisms. α-(4-Nitrobenzylidine) harmine (16) had a broad cytotoxicity spectrum (ED₅₀ values from 0.3-1.2 μg/mL against 1A9, KB, SaOS-2, A549, SK-MEL-2, U-87-MG, and MCF-7 cells).

Full text of DOI:10.1016/S0960-894X(99)00598-3

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