Bioorganic and Medicinal Chemistry Letters p. 3319 - 3324 (1999)
Update date:2022-08-10
Topics:
Ishida, Junko
Wang, Hui-Kang
Bastow, Kenneth F.
Hu, Chang-Qi
Lee, Kuo-Hsiung
Twenty-six β-carbolines were evaluated for in vitro cytotoxicity in a human tumor cell line panel. Harmine (3) showed significant activity against several cell lines including three drug-resistant KB sublines with various resistance mechanisms. α-(4-Nitrobenzylidine) harmine (16) had a broad cytotoxicity spectrum (ED50 values from 0.3-1.2 μg/mL against 1A9, KB, SaOS-2, A549, SK-MEL-2, U-87-MG, and MCF-7 cells).
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