Antitumor agents 201. Cytotoxicity of harmine and β-carboline analogs

DOI: 10.1016/S0960-894X(99)00598-3

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3319 - 3324 (1999)

Update date:2022-08-10

Topics:

Authors:

Ishida, Junko

Wang, Hui-Kang

Bastow, Kenneth F.

Hu, Chang-Qi

Lee, Kuo-Hsiung

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(99)00598-3

Twenty-six β-carbolines were evaluated for in vitro cytotoxicity in a human tumor cell line panel. Harmine (3) showed significant activity against several cell lines including three drug-resistant KB sublines with various resistance mechanisms. α-(4-Nitrobenzylidine) harmine (16) had a broad cytotoxicity spectrum (ED₅₀ values from 0.3-1.2 μg/mL against 1A9, KB, SaOS-2, A549, SK-MEL-2, U-87-MG, and MCF-7 cells).

Full text of DOI:10.1016/S0960-894X(99)00598-3

Products guided by the article

Product name:HARMOL

Cas No:487-03-6

R&D Labs maybe for 487-03-6

SINO GREAT ENTERPRISE LTD.

Contact:+86-731-84427351

Address:154 JIANXIANG SOUTH ROAD
NIGNXIA XINDACHANG TECHNOLOGY CO.,LTD

Contact:86-0951-7815345

Address:North side of Qiyuan Road, west side of Yuanfeng Highway, New Material Park, Ningdong Energy and Chemical Industry Base, Ningxia,China
Tianjin Dongchang Fine Chemical Industry Co., Ltd.

Contact:+86-22-29894595

Address:Economic Developing Zone, Ji County, Tianjin, China
Tianjin Anda North Industrial & Business Co.Ltd.

Contact:86-22-24999306

Address:No.11 Erwei Road,Dongli Development Area,Tianjin,China
Huzhou City Linghu Xinwang Chemical Co.,Ltd.

Contact:86-572-3948695/3945236

Address:huzhou

Relevant to this article

Evidence for a Ni^I active species in the catalytic cross-coupling of alkyl electrophiles

Doi:10.1021/ja0483903
(2004)
Synthesis and evaluation of a novel fluorescent chemosensor for glutathione based on a rhodamine B and N-[4-(carbonyl) phenyl]maleimide conjugate and its application in living cell imaging

Doi:10.1016/j.dyepig.2016.08.063
(2017)
Selective C-H Iodination of (Hetero)arenes

Doi:10.1021/acs.orglett.1c01530
(2021)
Fluorescence spectroscopic characterization of 4,7-bis(2-thienyl)-1,2,5-oxadiazolo[3,4-c]pyridine; lead structure of new red-emitting EL material

Doi:10.1016/S0009-2614(02)00147-1
(2002)
Doi:10.1002/adsc.201800206
(2018)
Zirconia-supported rhenium oxide as an efficient catalyst for the synthesis of biomass-based adipic acid ester

Doi:10.1039/c9cc05413h
(2019)

Article Doi