Synthetic and theoretical MO calculational studies of lithiotriazine intermediates produced during alkyllithium-induced cyclotrimerisation reactions of organic nitriles, and comparison of their structures with that of a methylmagnesiotriazine derivative

Article abstract of DOI:10.1016/0022-328X(94)05030-F

Benzonitrile can be readily cyclotrimerised by treatment with a suitable alkyllithium to give a simple triazine or to a solvated lithiodihydrotriazine derivative.Which cyclic product dominates depends mainly on the source of the active Li⁺ cation (n-butyllithium, t-butyllithium and tetramethylguanidinolithium are considered here), and on the solvent employed.X-ray crystallographic studies on a representative compound show that the lithio species exists as a mononuclear, contact ion pair structure, with the triazine ring in a 1,4-dihydro state.On reaction with theGrignard reagent, MeMgCl, this compound gives a methylmagnesiodihydrotriazine, which has also been crystallographically characterised and found to closely resemble its lithio precursor.Ab initio MO calculations on model systems reveal that the 1,4-dihydrotriazine arrangements is energetically preferred to the 1,2-dihydro alternative irrespective of the counterion (Li⁺ or H⁺) present.A theoretical investigation of the methanolysis of the lithio species indicates that the formation of an intermediate MeOH complex, with the alcohol attached to a ring N atom and not to Li⁺, directs the reaction towards ultimate formation of a 1,2-dihydrotriazine.Keywords: Triazine; Lithium; Magnesium; Ab initio; Crystal structure