KINETICS OF OXIDATION OF KETOGLUTARIC ACIDS BY ALKALINE CHLORAMINE-T SOLUTION

Article abstract of DOI:10.1016/S0040-4020(01)87492-5

Kinetics of the oxidation of α-ketoglutaric and β-ketoglutaric acids by chloramine-T (CAT) have been investigated in highly alkaline media.The reactions show first order dependence in chloramine-T and fractional order in substrates.The order in hydroxide ions has been found to be second but shows a slight decrease at high concentration of alkali.No effect of p-toluene-sulphonamide was evident.Observed stoichiometry, positive effects of ionic strength and dielectric constant point to a mechanism involving formation of an intermediate in a termolecular rate determining slowest step among hypochlorite ion, hydroxide ion and enolic anion of keto acids followed by a fast step leading to products.Activation parameters have been computed and formaldehyde and formic acid were identified as end-products.