Natural Product Research p. 3521 - 3526 (2019)
Update date:2022-08-31
Topics:
Fotso, Ghislain
Na-Iya, Jean
Mbaveng, Armelle
Ango Yves, Patrick
Demirtas, Ibrahim
Kuete, Victor
Samuel, Yeboah
Ngameni, Bathelemy
Efferth, Thomas
Ngadjui, Bonaventure
The chemical investigation of the leaves and stem bark of Acacia polyacantha (Fabaceae) led to the isolation of a new oleanane-type triterpenoid saponin named polyacanthoside A 1 together with fifteen known compounds. Their structures were established from spectral, mainly HRESIMS, 1D NMR and 2D NMR and by comparison with literature data. The cytotoxicity of compound 1 and the analogues 8 as well as doxorubicin was determined in a panel of 9 cancer cell lines including sensitive and drug resistant phenotypes. Unlike the analogue 8, compound 1 as well as doxorubicin displayed cytotoxic effects in all the 9 tested cancer cell lines with IC50 values ranged from 8.90 μM (towards CCRF-CEM leukemia cells) to 35.21 μM (towards HepG2 hepatocarcinoma cells) for compound 1 and from 0.02 μM (towards CCRF-CEM leukemia cells) to 66.83 μM (against CEM/ADR5000 leukemia cells) for doxorubicin.
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Doi:10.13005/ojc/350150
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(2018)