Penicillin Biosynthesis: Active Site Mapping with Aminoadipoylcysteinylvaline

DOI: 10.1039/c39840001225

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 1225 - 1227 (1984)

Update date:2022-08-12

Topics:

Authors:

Baldwin, Jack E.

Abraham, Edward P.

Adlington, Robert M.

Bahadur, Gulam A.

Chakravarti, Bulbul

et al. et al.

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Article abstract of DOI:10.1039/c39840001225

A series of structural variants on the aminoadipoyl moiety of the natural precursor of penicillins, δ-(L-α-aminoadipoyl)-L-cysteinyl-D-valine, have been synthesised and their effectiveness as substrates for the enzyme isopenicillin N synthetase has been determined.

Full text of DOI:10.1039/c39840001225

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