Incorporation of an intramolecular hydrogen-bonding motif in the side chain of 4-aminoquinolines enhances activity against drug-resistant P. falciparum

DOI: 10.1021/jm0600951

Source and publish data:

Journal of Medicinal Chemistry p. 4535 - 4543 (2006)

Update date:2022-08-11

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Authors:

Madrid, Peter B.

Liou, Ally P.

DeRisi, Joseph L.

Guy, R. Kiplin

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Article abstract of DOI:10.1021/jm0600951

Previous data showing that several chloroquine analogues containing an intramolecular hydrogen-bonding motif were potent against multidrug-resistant P. falciparum led to the exploration of the importance of this motif. A series of 116 compounds containing

Full text of DOI:10.1021/jm0600951

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