110
because heparin administration reduces the serum VEGF28
and increases the serum HGF concentration.45 Second, we
measured only the serum concentrations of VEGF and
HGF and did not evaluate the local concentrations of
VEGF and HGF in the ischemic regions. Further studies
based on blood sampling from the coronary sinus and aorta
are needed to determine the main site of VEGF/HGF pro-
duction in patients with coronary artery disease.
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