Pyrimidine nucleotidases/phosphotransferases from human erythrocyte

Article abstract of DOI:10.1080/15257779908041580

Two cytoplasmic pyrimidine 5'-nucleotidase have been purified from human erythrocytes to homogeneity and partially characterized. The two enzymes, indicated as PN-I and PN-II, preferentially hydrolyse pyrimidine 5'- monophosphates and 3'-monophosphates, respectively. The kinetic analysis demonstrate that pyrimidine 5'-nucleotidases, in the presence of suitable nucleoside substrates, can operate as phosphotransferases by transferring phosphate to various nucleoside acceptors, including nucleoside analogues known as important drugs widely used in chemotherapy.

Full text of DOI:10.1080/15257779908041580

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Nucleosides and Nucleotides
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Pyrimidine Nucleotidases/
Phosphotransferases from Human
Erythrocyte
A. Amici a , M. Emanuelli a , N. Raffaelli a , S. Ruggieri b & G. Magni a
a Istituto di Biochimica, Università di Ancona, Facoltà di Medicina e
Chirurgia , Via Ranieri, 60131, Ancona, Italy
b Dipartimento di Biotecnologie Agrarie ed Ambientali , Università di
Ancona , Via Ranieri, 60131, Ancona, Italy
Published online: 04 Oct 2006.
To cite this article: A. Amici , M. Emanuelli , N. Raffaelli , S. Ruggieri & G. Magni (1999) Pyrimidine
Nucleotidases/Phosphotransferases from Human Erythrocyte, Nucleosides and Nucleotides, 18:4-5,
853-855, DOI: 10.1080/15257779908041580
To link to this article: http://dx.doi.org/10.1080/15257779908041580
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