Preparation And Antileukemic Activity Of Congeners Of Tropoloisoquinoline Alkaloids From Abuta Concolor

Article abstract of DOI:10.3987/COM-93-S108

Antileukemic tropoloisoquinoline alkaloids, pareirubine A (1) and grandirubrine (2), at first have been isolated from Abuta concolor (Menispermaceae).Methylation of 1 and 2, existing in solution as a mixture of tautomers gave the corresponding four methyl derivatives (3 - 6).Thioimerubrine (7) and thioisoimerubrine (8) were prepared by the nucleophilic substitutions of the methoxyl groups at C-11 and -10, respectively.Acetylation of 1 and 2 produced the corresponding mono-acetyl tautomers (9 and 10).Antileukemic activity of these derived tropoloisoquinoline alkaloids is also reported.