Thioalkyl derivatives of vitamin K3 and vitamin K3 oxide inhibit growth of Hep3B and HepG2 cells

Article abstract of DOI:10.1006/bioo.1995.1008

A new hypothesis regarding the effect of vitamin K₃ on hepatoma cell growth is presented. In brief, exploration of cell growth activity has been identified with the action of p34(cdc2) kinase and its associated protein tyrosine phosphatase. After exploring a series of substituted derivatives of vitamin K and vitamin K₃ oxide, we suggest a mechanism involving alkylation at the active-site cysteine for the inhibition of the protein tyrosine phosphatase which controls the activity of the p34(cdc2) kinase.