Rhodium-catalyzed Synthesis of 1-Arylisoquinoline Derivatives through Annulative Coupling of 3-Aryl-1, 2-benzisoxazoles and Alkynes

Article abstract of DOI:10.1246/cl.170618

Direct annulative coupling of 3-aryl-1, 2-benzisoxazoles and alkynes efficiently proceeds in the presence of a Cp^?Rh(III) catalyst to produce 2-(1-isoquinolinyl)phenols of interest in medicinal chemistry as well as materials chemistry. The products may also be useful precursors of quinoline-based bidentate ligands.