Journal of the American Chemical Society
Page 24 of 32
1
2
3
4
5
6
7
8
(15) Berim, A.; Hyatt, D. C.; Gang, D. R. A set of regioselective O-methyltransferases gives rise to the
complex pattern of methoxylated flavones in sweet basil. Plant Physiol. 2012, 160, 1052–1069.
(16) Joe, E. J.; Kim, B. G.; An, B. C.; Chong, Y.; Ahn, J. H. Engineering of flavonoid O-methyltransferase
for a novel regioselectivity. Mol. Cells. 2010, 30, 137–141.
(17) Wils, C. R.; Brandt, W.; Manke, K.; Vogt, T. A single amino acid determines position specificity of
an Arabidopsis thaliana CCoAOMT-like O-methyltransferase. FEBS letters. 2013, 587, 683–689.
(18) Shen, W.; Mao, H.; Huang, Q.; Dong, J. Benzenediol lactones: A class of fungal metabolites with
diverse structural features and biological activities. Eur. J. Med. Chem. 2015, 97, 747–777.
(19) Patocka, J.; Soukup, O.; Kuca, K. Resorcylic acid lactones as the protein kinase inhibitors, naturally
occuring toxins. Mini Rev. Med. Chem. 2013, 13, 1873–1878.
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
(20) Liu, Z.; Zheng, X.; Wang, Y.; Tang, M.; Chen, S.; Zhang, F.; Li, L.; Zhang, C.; Sun, Y. Lignans and
isoflavonoids from the stems of Pisonia umbellifera. RSC Adv. 2018, 8, 16383–16391.
(21) Xu, Y.; Zhou, T.; Espinosa-Artiles, P.; Tang, Y.; Zhan, J.; Molnár, I. Insights into the biosynthesis of
12-membered resorcylic acid lactones from heterologous production in Saccharomyces cerevisiae.
ACS Chem. Biol. 2014, 9, 1119–1127.
(22) Xu, Y.; Espinosa-Artiles, P.; Schubert, V.; Xu, Y.-M.; Zhang, W.; Lin, M.; Gunatilaka, A. L.;
Süssmuth, R.; Molnár, I. Characterization of the biosynthetic genes for 10,11-dehydrocurvularin, a
heat shock response-modulating anticancer fungal polyketide from Aspergillus terreus. Appl. Environ.
Microbiol. 2013, 79, 2038–2047.
(23) Wang, S.; Xu, Y.; Maine, E. A.; Wijeratne, E. K.; Espinosa-Artiles, P.; Gunatilaka, A. L.; Molnár, I.
Functional characterization of the biosynthesis of radicicol, an Hsp90 inhibitor resorcylic acid lactone
from Chaetomium chiversii. Chem. Biol. 2008, 15, 1328–1338.
(24) Xu, Y.; Zhou, T.; Zhang, S.; Xuan, L. J.; Zhan, J.; Molnár, I. Thioesterase domains of fungal
nonreducing polyketide synthases act as decision gates during combinatorial biosynthesis. J. Am.
Chem. Soc. 2013, 135, 10783–10791.
(25) Bai, J.; Lu, Y.; Xu, Y.-M.; Zhang, W.; Chen, M.; Lin, M.; Gunatilaka, A. L.; Xu, Y.; Molnár, I.
Diversity-oriented combinatorial biosynthesis of hybrid polyketide scaffolds from azaphilone and
benzenediol lactone biosynthons. Org. Lett. 2016, 18, 1262–1265.
(26) Xu, Y.; Zhou, T.; Zhang, S.; Espinosa-Artiles, P.; Wang, L.; Zhang, W.; Lin, M.; Gunatilaka, A. L.;
Zhan, J.; Molnár, I. Diversity-oriented combinatorial biosynthesis of benzenediol lactone scaffolds by
subunit shuffling of fungal polyketide synthases. Proc. Natl. Acad. Sci. U.S.A. 2014, 111, 12354–
12359.
(27) Xu, Y.; Zhou, T.; Zhou, Z.; Su, S.; Roberts, S. A.; Montfort, W. R.; Zeng, J.; Chen, M.; Zhang, W.;
Lin, M.; Zhan, J.; Molnár, I. Rational reprogramming of fungal polyketide first-ring cyclization. Proc.
Natl. Acad. Sci. U.S.A. 2013, 110, 5398–5403.
(28) Xie, L.; Zhang, L.; Wang, C.; Wang, X.; Xu, Y.-M.; Yu, H.; Wu, P.; Li, S.; Han, L.; Gunatilaka, A.
L.; Wei, X.; Lin, M.; Molnár, I.; Xu, Y. Methylglucosylation of aromatic amino and phenolic moieties
ACS Paragon Plus Environment