NEO-CLERODANE DITRPENOIDS FROM TEUCRIUM MASSILIENSE

Article abstract of DOI:10.1016/S0031-9422(00)85040-2

From the aerial part of Teucrium massiliense three new neo-clerodane diterpenoids, deacetylajugarin-II, teumassilin and 6,19-diacetylteumassilin, have been isolated, besides the previously known diterpenes montanin C and teucjaponin A.The structures of deacetylajugarin-II (4α,18-epoxy-6α,19-dihydroxy-neo-clerodan-13-en-15,16-olide), teumassilin (4α,18:15,16-diepoxy-6α,12S,19-trihydroxy-neo-cleroda-13(16),14-diene) and 6,19-diacetylteumassilin (6α,19-diacetoxy-4α,18:15,16-diepoxy-12S-hydroxy-neo-cleroda-13(16),14-diene) were established by chemical and spectroscopic means.In addition, the previously known flavones salvigenin and cirsimaritin have also been obtained from the same source.Key Word Index - Teucrium massiliense; Labiatae; diterpenoids; neo-clerodane derivatives; teumassilin; 6,19-diacetylteumassilin; deacetylajugarin-II; montanin C; teucjaponin A.