Angewandte Chemie - International Edition p. 15069 - 15079 (2021)
Update date:2022-08-29
Topics:
Baumer, Katelyn M.
Beard, Alexandra A.
Borchelt, David R.
Chen, Zhijuan
Cook, Christopher D.
Dashnaw, Chad M.
Koone, Jordan C.
Shaw, Bryan F.
Solouki, Touradj
Villacob, Raul A.
Wood, John L.
Zahler, Collin T.
Repulsive electrostatic forces between prion-like proteins are a barrier against aggregation. In neuropharmacology, however, a prion's net charge (Z) is not a targeted parameter. Compounds that selectively boost prion Z remain unreported. Here, we synthes
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