Biological and Pharmaceutical Bulletin p. 1784 - 1786 (1995)
Update date:2022-08-23
Topics:
Maria
Wendel
Guardia
Guzman
Pestchanker
Guerreiro
Giordano
The cytoprotective activity of the isolated functional groups of several sesquiterpene lactones is reported. Among them the highest activity is shown by α-methylen-γ-butyrolactone and 2-cyclopenten-1-one. The activity shown by those Michael acceptors with a β carbon hindered by an alkyl substituent was always lower or almost null. A three-way mechanism of action is proposed: a) reduced glutathione synthesis, b) prostaglandin synthesis and c) mucosal glycoprotein synthesis.
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