New Journal of Chemistry p. 15879 - 15894 (2018)
Update date:2022-08-11
Topics:
Kaushal, Mani
Lobana, Tarlok S.
Nim, Lovedeep
Kaur, Jaskamal
Bala, Ritu
Hundal, Geeta
Arora, Daljit S.
Garcia-Santos, Isabel
Duff, Courtney E.
Jasinski, Jerry P.
Pyridine-2-formaldehyde-N1-substituted-thiosemicarbazones {(C5H4N4)HC2═N3-N2(H)-C1═(S)N1HR} (abbrev. HL1-R: R = Me, Et, Ph) with copper(i) halides in an acetonitrile-dichloromethane mixture (1?:?1, v/v) have yielded a novel series of CuII complexes with a central coordination core: [CuIIX(N,N,S-L1-R)] (R = Me, Et, Ph: X = I, 1-3; Br, 4-6, Cl, 7-9), which have been characterized with the help of analytical data, IR, UV-visible and ESR spectroscopy, ESI-mass spectrometry and single crystal X-ray crystallography. The thio-ligands coordinate to CuII as anions (L1-R)? through pyridyl nitrogen-N4, azomethine nitrogen-N3 and thiolato sulfur and CuII is further bonded to iodide, bromide or chloride. In order to explore their bio-activity, complexes (1-9) as well as the previously reported CuII complexes of 2-benzoylpyridine-N-substituted thiosemicarbazones {(C5H4N4)(C6H5)-C2═N3-N2(H)-C1═(S)-N1HR; HL2-R}, namely, [CuIIX(N,N,S-L2-R)] (R = Me, Et, Ph: X = I, 10-12; Br, 13-15; Cl, 16-18), have been evaluated for their antimicrobial potential against different microbial strains. The microbial strains investigated are Staphylococcus aureus (MTCC740), Klebsiella pneumoniae (MTCC530), Shigella flexneri (MTCC1457), Salmonella typhimurium 1 (MTCC98), Salmonella typhimurium 2 (MTCC1251), Escherichia coli (MTCC119), Staphylococcus epidermidis (MTCC435), methicillin resistant Staphylococcus aureus (MRSA) and a yeast culture Candida albicans (MTCC227). Several complexes tested have shown high antimicrobial activity; specifically, against methicillin resistant Staphylococcus aureus, Staphylococcus epidermidis and Salmonella typhimurium 2; the activity is found to be high at low minimum inhibitory concentration (MIC) values as compared to that of the standard Gentamicin. Using MTT cytotoxicity assay {MTT = 3-[(4,5-dimethylthiazol-2-yl)-2,5-diphenyl]tetrazolium bromide}, complexes tested were found to be biosafe with high cell viability (90-98%).
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