Macromolecules
Article
organized micelle structures in an aqueous environment. The
micelles which were formed were characterized by the use of
fluorescence techniques, dynamic light scattering, and trans-
mission electron microscopy. The critical micelle concen-
trations of the block copolymers were determined from
fluorescence spectra using pyrene as a probe. The cmc values
depended on the proportion of the hydrophobic blocks in the
copolymer and were in the range of 3.47−9.55 mg/L. TEM and
dynamic light scattering results indicated that the spherical
micelle aggregates were formed with an average diameter of
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(
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1
00−142 nm. The hydrophobicity of the micellar core was
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estimated by measurement of the partition equilibrium constant
of pyrene in the micelle solution, and the values were in the
range of 0.12 × 10 to 1.52 × 10 . The combination of “click”
reaction chemistry, and ATRP has opened a new facile route
5
5
(
2
(
(
(
008, 33, 759−785.
(
“block-from”) for synthesizing well-defined hybrid phosphazene−
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organic block copolymer structures with high synthetic
tunability. The properties of the micelles can be tailored by
changing either the phosphazene block or the organic block
following the synthetic procedures described above. This can be
achieved by varying the nucleophiles during the substitution of
poly(dichlorophosphazene) or by varying the organic mono-
mers during ATRP. For instance, to synthesize block
copolymers containing biodegradable substituents, similar
synthetic procedures can be followed except the side group
nucleophiles used could be changed to amino acid esters
instead of the trifluoroethoxy group to confer biodegradability
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1
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to the micelles.
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(
9
(
181.
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AUTHOR INFORMATION
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*
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Notes
The authors declare no competing financial interest.
(
van Delft, F. L.; Cornelissen, J. J. L. M.; Rowan, A. E.; van Hest, J. C.
M.; Rutjes, F. P. J. T.; Nolte, R. J. M. Chem. Commun. 2005, 33, 4172−
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dx.doi.org/10.1021/ma300139z | Macromolecules 2012, 45, 2502−2508