The mode of substrate-recognition mechanism of arylmalonate decarboxylase

Article abstract of DOI:10.1246/cl.1997.351

A mode of substrate-recognition mechanism by an enzyme, arylmalonate decarboxylase, is proposed. ¹⁹F-and ³¹P-NMR spectra of a complex consisting of the enzyme and an active site-directed inhibitor demonstrated that a hydrophobic interaction between the enzyme and its substrate via their aromatic rings was especially important for the enzyme function.