NEW METHODS AND REAGENTS IN ORGANIC SYNTHESIS. 51. A SYNTHESIS OF ASCIDIACYCLAMIDE, A CYTOTOXIC CYCLIC PEPTIDE FROM ASCIDIAN - DETERMINATION OF ITS ABSOLUTE CONFIGURATION

Article abstract of DOI:10.1016/S0040-4039(00)98157-7

A first synthesis of ascidiacyclamide, a cytotoxic cyclic peptide from ascidian, has been achieved through the cyclodimerization with diphenyl phosphorazidate (DPPA), wich has unambiguously determined the absolute configuration of ascidiacyclamide as 1.