Formation of Quasi-racemic Diastereoisomeric Salts as a Structural Cause for Efficient Optical Resolution

Article abstract of DOI:10.1016/00404-0399(50)09415-

During optical resolutions, when the resolving agent is structurally similar to the racemate, very efficient resolution can be achieved, because of the formation of quasi-racemic diastereoisomeric salts, in which the enantiomers have opposite configuration.