Synthesis of the C6-C16 polyene fragment of ratjadone, a potent cytotoxic metabolite from Sorangium cellulosum

Article abstract of DOI:10.1016/S0040-4039(99)00716-9

The Pd-catalyzed synthesis of the polyene fragment of ratjadone is described. This strategy employs the Stille-coupling for the coupling of the tetrahydropyran subunit and the Suzuki coupling for attaching the unsaturated lactone to the polyene chain.